Effect of smoking on lung function, respiratory symptoms and respiratory diseases amongst HIV-positive subjects: a cross-sectional study | Cui et al. AIDS Research and Therapy 2010 7 6 http content 7 1 6 AIDS RESEARCH AND THERAPY RESEARCH Open Access Effect of smoking on lung function respiratory symptoms and respiratory diseases amongst HIV-positive subjects a cross-sectional study 1 2 3 4 11 2 3 4 Qu Cui Sue Cdnuu lers Andrew mcivoi FiUlM Silldill Lei Idl Id II Idbdl ie Mdrek SI lliejd Abstract Background Smoking prevdlence in humdn immunodeficiency virus HIV positive subjects is dbout three times of thdt in the general populdtion. However whether the extremely high smoking prevdlence in HIV-positive subjects dffects their lung function is uncledr pdrticuldrly whether smoking decredses lung function more in HIV-positive subjects compdred to the general populdtion. We conducted this study to determine the dssocidtion between smoking dnd lung function respiratory symptoms dnd disedses dmongst HIV-positive subjects. Results Of 120 enrolled HIV-positive subjects 119 hdd dn dcceptdble spirogram. Ninety-four 79 subjects were men dnd 96 81 were white. Medn stdnddrd devidtion SD dge wds yedrs. Medn SD of forced expiratory volume in one second FEV1 percent of dge gender race dnd height predicted vdlue FEV1 wds . Seventy-five 63 subjects hdd smoked pdck-yedrs. For every ten pdck-yedrs of smoking increment FEV1 decredsed by 95 confidence intervdl CI dfter controlling for gender race dnd restrictive lung function R2 . The loss of FEV1 in our subjects wds compdrdble to the general populdtion. Compdred to non-smokers current smokers hdd higher odds of cough sputum or bredthlessness dfter ddjusting for highly dctive dnti-retrovirdl therdpy HAARI use odds rdtio OR 95 CI . However respirdtory symptom presence wds simildr between non-smokers dnd former smokers OR 95 CI . All four cdses of COPD chronic obstructive pulmondry disedse hdd smoked. Four of ten cdses of restrictive lung disedse hdd smoked p dnd three of .
