Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir. | Jong et al. AIDS Research and Therapy 2010 7 9 http content 7 1 9 AIDS RESEARCH AND THERAPY SHORT REPORT Open Access Ma rkers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir Eefje Jong 1 2 Joost CM Meijers3 Eric CM van Gorp1 4 C Arnold Spek5 and Jan W Mulder1 Abstract Background Abacavir ABC treatment has been associated with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral therapy with or without ABC were examined to pinpoint a pathogenic mechanism. Given the important role of high sensitivity C-reactive protein hsCRP levels in predicting cardiovascular risk patient groups were also analyzed according to hsCRP levels. Methods Patients treated with ABC and a matched control group treated without ABC were selected retrospectively. Vascular endothelial growth factor VEGF and markers of endothelial cell activation von Willebrand factor vWF factor VIII fibrin formation fibrinogen D-dimer prothrombin fragment 1 2 F1 2 endogenous thrombin potential ETP anticoagulation markers protein C and S activated protein C sensitivity ratio APCsr and inflammation markers IL-6 hsCRP were measured in citrated plasma. Results A total of 81 patients were included of whom 27 patients used an ABC-containing regimen and 54 used a non-ABC-containing regimen. Patient characteristics were not significantly different between the groups except for longer duration of use of the current antiretroviral regimen in the ABC group p . The median time on ABC was 68 months interquartile range 59-80 months . No differences in coagulation and inflammation markers according to ABC use were observed. For the whole patient group elevated vWF and F1 2 levels were observed in 23 and 37 respectively. Compared to the reference ranges
