Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites. | Holman et al. AIDS Research and Therapy 2010 7 43 http content 7 1 43 AIDS RESEARCH AND THERAPY RESEARCH Open Access HIVBrainSeqDB a database of annotated HIV envelope sequences from brain and other anatomical sites Alexander G Holman1 Megan E Mefford1 Niall O Connor2 Dana Gabuzda1 3 Abstract Background The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30 of infected individuals and is a viral sanctuary site for the development of drug resistance. The primary determinant of HIV neurotropism is macrophage tropism which is primarily determined by the viral envelope env gene. However studies of genetic aspects of HIV replicating in the brain are hindered because existing repositories of HIV sequences are not focused on neurotropic virus nor annotated with neurocognitive and neuropathological status. To address this need we constructed the HIV Brain Sequence Database. Results The HIV Brain Sequence Database is a public database of HIV envelope sequences directly sequenced from brain and other tissues from the same patients. Sequences are annotated with clinical data including viral load CD4 count antiretroviral status neurocognitive impairment and neuropathological diagnosis all curated from the original publication. Tissue source is coded using an anatomical ontology the Foundational Model of Anatomy to capture the maximum level of detail available while maintaining ontological relationships between tissues and their subparts. 44 tissue types are represented within the database grouped into 4 categories i brain brainstem and spinal cord ii meninges choroid plexus and CSF iii blood and lymphoid and iv other bone marrow colon lung liver etc . Patient coding is correlated across studies allowing sequences from the same patient to be grouped to .
