Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study. | Ho et al. AIDS Research and Therapy 2011 8 17 http content 8 1 17 AIDS RESEARCH AND THERAPY RESEARCH Open Access Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection results of a pilot study 14 1 2 3 1 Emily L Ho Serena S Spudich Evelyn Lee Dietmar Fuchs Elizabeth Sinclair and Richard W Price Abstract Background Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system CNS lentivirus infection immune activation and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection we conducted an open-labelled pilot study of its effects on cerebrospinal fluid CSF and blood biomarkers of infection and immune responses in 7 viremic subjects not taking antiretroviral therapy. Results There were no discernable effects of minocycline on CSF or blood HIV-1 RNA or biomarkers of immune activation and inflammation including CSF and blood neopterin CSF CCL2 CSF white blood cell count and expression of cell-surface activation markers on CSF and blood T lymphocytes and monocytes. Conclusions This pilot study of biological responses to minocycline suggests little potential for its use as adjunctive antiviral or immunomodulating therapy in chronic untreated HIV infection. Background Human immunodeficiency virus type one HIV infection of the central nervous system CNS is a nearly ubiquitous facet of systemic infection that begins early after exposure 1-6 . This CNS infection is accompanied by local immune responses that are reflected in elevations of CSF biomarkers of immune activation and inflammation 7-11 . Though clinically inapparent in most patients CNS HIV infection evolves in some to a more invasive HIV encephalitis HIVE that manifests with the cognitive and motor dysfunction characteristic of the AIDS dementia complex ADC 12 now commonly referred to as HIV-associated dementia HAD 13 . .
