Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats. | Clary et al. AIDS Research and Therapy 2011 8 30 http content 8 1 30 AIDS RESEARCH AND THERAPY RESEARCH Open Access Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats Caroline R Clary Daniel M Guidot Margaux A Bratina and Jeffrey S Otis Abstract Background Separately chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements including atrophy and wasting weakness and fatigue. One prospective cohort study reported that 41 of HIV-infected patients met the criteria for alcoholism however few reports exist on the co-morbid effects of these two disease processes on skeletal muscle homeostasis. Thus we analyzed the atrophic effects of chronic alcohol ingestion in HIV-1 transgenic rats and identified alterations to several catabolic and anabolic factors. Findings Relative plantaris mass total protein content and fiber cross-sectional area were reduced in each experimental group compared to healthy control-fed rats. Alcohol abuse further reduced plantaris fiber area in HIV-1 transgenic rats. Consistent with previous reports gene levels of myostatin and its receptor activin IIB were not increased in HIV-1 transgenic rat muscle. However myostatin and activin IIB were induced in healthy and HIV-1 transgenic rats fed alcohol for 12 weeks. Catabolic signaling factors such as TGFP1 TNFa and phospho-p38 total-p38 were increased in all groups compared to controls. There was no effect on IL-6 leukemia inhibitory factor LIF cardiotrophin-1 CT-1 or ciliary neurotrophic factor CNTF in control-fed transgenic rats. However the comorbidity of chronic alcohol abuse and HIV-1-related protein expression decreased expression of the two anabolic factors CT-1 and CNTF. Conclusions Consistent with previous reports alcohol abuse accentuated skeletal muscle atrophy in an animal model of HIV AIDS. While some catabolic pathways known to drive alcoholic or HIV-1-associated myopathies were also .
