cây phát sinh loài của nhánh đánh dấu sinh flaviviruses: cây sự đồng thuận dựa trên 1 và vị trí codon 2 cho 41 gen E và trình tự gen NS5, lấy từ Gould et al. (2001) và et al Gaunt. (2001). Nguồn gốc của các trình tự gen được sử dụng để xây dựng cây này được đưa ra trong các ấn phẩm | TICK-BORNE DISEASE SYSTEMS 271 UK Sheep N Spain or goats Greece Bulgaria Turkey Central Europe Central Siberia w Russia to Far East ts Omsk SE Asia India Island off Australia or Asia rials Uzbekistan POW N America KAD J Africa MEA SRE ---TYU NW France Seabirds Great Barrier Reef E coast Russia Figure 1 Phylogenetic tree of the tick-borne clade of flaviviruses consensus tree based on the 1st and 2nd codon positions for 41 E genes and the NS5 gene sequence taken from Gould et al. 2001 and Gaunt et al. 2001 . The source of the gene sequences used to construct this tree is given in the original publications. The genus Flavivirus contains about 70 distinct an-tigenically related flaviviruses. These are positive-stranded RNA viruses that consist of three structural proteins C capsid M membrane and E envelope and seven non-structural NS proteins. TYU Tyuleniy SRE Saumarez Reef MEA Meaban KAD Kadam POW Powassan KSI Karshi RF Royal Farm GGY Gadget s Gully KFD Kyasanur Forest disease LGT Langat OHF Omsk haemorrhagic fever FETBE Far Eastern tick-borne encephalitis STBE Siberian tick-borne encephalitis WTBE Western tick-borne encephalitis TSE Turkish sheep encephalitis GGE Greek goat encephalitis SSE Spanish sheep encephalitis LI Louping ill. Principal vertebrate host types and the geographical distribution are shown. Thus within the mammal-associated lineage the viruses of Southeast Asia KFD and LGT are the ancestors of the viruses of the northern forests of central Russia Far East and Siberia OHF FETBE and STBE which in turn are the ancestors of the viruses of eastern and central Europe WTBE TSE GGE culminating in a virus found only in northern Spain SSE and the most westerly virus LI found in the British Isles. It is only these last four viruses that are transmitted via sheep and LI is evidently also transmissible via red Plate A The distribution of geo-referenced sites of known presence of TBE complex flaviviruses used in this analysis. In addition to those shown .
