Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: 24-hour changes in circulating prolactin, follicle-stimulating hormone, luteinizing hormone and testosterone in male rats subjected to social isolation. | Journal of Circadian Rhythms BioMed Central Research Open Access 24-hour changes in circulating prolactin follicle-stimulating hormone luteinizing hormone and testosterone in male rats subjected to social isolation Ana I Esquifino1 Fernando Chacón1 Vanessa Jimenez1 Carlos F Reyes Toso2 and Daniel P Cardinali 2 Address 1Departamento de Bioquímica y Biología Molecular III Facultad de Medicina Universidad Complutense Madrid Spain and 2Departamento de Fisiología Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina Email Ana I Esquifino - pelayos@ Fernando Chacón - pelayos@ Vanessa Jimenez - pelayos@ Carlos F Reyes Toso - creyestoso@ Daniel P Cardinali - cardinal@ Corresponding author Published 20 February 2004 Received 24 December 2003 Accepted 20 February 2004 Journal of Circadian Rhythms 2004 2 1 This article is available from http content 2 1 1 2004 Esquifino et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background This work analyzes the effect of social isolation a mild stressor on the 24-h variation of pituitary-testicular function in young Wistar rats assessed by measuring circulating levels of prolactin FSH LH and testosterone. Methods Animals were either individually caged or kept in groups 4-5 animals per cage under a 12 12 h light-dark cycle lights on at 0800 h for 30 days starting on day 35 of life. Rats were killed at 4-h intervals during a 24-h cycle beginning at 0900 h. Results Isolation brought about a decrease in prolactin LH and testosterone secretion and an increase of FSH secretion. In isolated rats the 24-h secretory pattern of prolactin and testosterone became modified . the maximum in prolactin seen in control animals at the beginning of the .
