Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice./ | Journal of Circadian Rhythms BioMed Central Research Open Access A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice John R Hofstetter Doreen A Svihla-Jones and Aimee R Mayeda Address Department of Psychiatry Richard L. Roudebush Veterans Administration Medical Center VAMC Indianapolis IN 46202 USA Email John R Hofstetter - jhofstet@ Doreen ASvihla-Jones - dajones3030@ Aimee R Mayeda - amayeda@ Corresponding author Published 31 October 2007 Received 27 August 2007 . J_ .IA I ioz i- a- - Ai C-T Accepted 31 October 2007 Journal of Circadian Rhythms 2007 5 7 doi 1740-3391-5-7 This article is available from http content 5 1 7 2007 Hofstetter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Many genes control circadian period in mice. Prior studies suggested a quantitative trait locus QTL on proximal mouse chromosome 12 for interstrain differences in circadian period. Since the J strain has DBA 2 alleles for a portion of proximal chromosome 12 introgressed onto its C57BL 6J background we hypothesized that these mice would have a shorter circadian period than C57BL 6J mice. Methods We compared circadian phenotypes of J and C57BL 6 mice period of general locomotor activity in constant dark and rest activity pattern in alternating light and dark. We genotyped the J mice to characterize the size of the genomic insert. To aid in identifying candidate quantitative trait genes we queried databases about the resident SNPs whole brain gene expression in C57BL 6J versus DBA 2J mice and circadian patterns of gene expression. Results The J .
