Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Circadian rhythm and its role in malignancy. | Rana and Mahmood Journal of Circadian Rhythms 2010 8 3 http content 8 1 3 JOURNAL OF CIRCADIAN RHYTHMS REVIEW Open Access Circadian rhythm and its role in malignancy Sobia Rana1 Saqib Mahmood2 Abstract Circadian rhythms are daily oscillations of multiple biological processes directed by endogenous clocks. The circadian timing system comprises peripheral oscillators located in most tissues of the body and a central pacemaker located in the suprachiasmatic nucleus SCN of the hypothalamus. Circadian genes and the proteins produced by these genes constitute the molecular components of the circadian oscillator which form positive negative feedback loops and generate circadian rhythms. The circadian regulation extends beyond clock genes to involve various clock-controlled genes CCGs including various cell cycle genes. Aberrant expression of circadian clock genes could have important consequences on the transactivation of downstream targets that control the cell cycle and on the ability of cells to undergo apoptosis. This may lead to genomic instability and accelerated cellular proliferation potentially promoting carcinogenesis. Different lines of evidence in mice and humans suggest that cancer may be a circadian-related disorder. The genetic or functional disruption of the molecular circadian clock has been found in various cancers including breast ovarian endometrial prostate and hematological cancers. The acquisition of current data in circadian clock mechanism may help chronotherapy which takes into consideration the biological time to improve treatments by devising new therapeutic approaches for treating circadian-related disorders especially cancer. Introduction In humans like other organisms most physiological and behavioral functions are manifested rhythmically across days and nights. All healthy human beings exhibit the common attribute of sleeping at night and waking up in the morning automatically. When a human being encounters a new .
