Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment of gram-positive deep sternal wound infections in cardiac surgery -experiences with . | Popov et al. Journal of Cardiothoracic Surgery 2011 6 112 http content 6 1 112 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Treatment of gram-positive deep sternal wound infections in cardiac surgery -experiences with daptomycin- 1 1 1 2 Aron F Popov Jan D Schmitto Ahmad F Jebran Christian Bireta Martin Friedrich Direndra Rajaruthnam 1 S r I m trl l I 1 A I KỲ IZM 4 I_I I 74 I I I K I I r I I m I r 1 I c M r I r L A c r o L . .r-J I I L . s- 1 Kasim O Coskun Anselm Braeuer Jose Hinz Theodor Tirilomis and Friedrich A SChoendUbe Abstract The reported incidence of deep sternal wound infection DSWI after cardiac surgery is with Staphylococcus aureus being the most common pathogen isolated from infected wound sternotomies and bacteraemic blood cultures. This infection is associated with a higher morbidity and mortality than other known aetiologies. Little is reported about the optimal antibiotic management. The aim of the study is to quantify the application of daptomycin treatment of DSWI due to gram-positive organisms post cardiac surgery. We performed an observational analysis in 23 cases of post sternotomy DSWI with gram-positive organisms February 2009 and September 2010. When the wound appeared viable and the microbiological cultures were negative the technique of chest closure was individualised to the patient. The incidence of DSWI was . The mean dose of daptomycin application was mg kg d and the average duration of the daptomycin application was days. In 89 of the patients VAC therapy was used. The duration from daptomycin application to sternal closure was 18 days. The parameters of infection including fibrinogen p white blood cell count p and C-reactive protein p were significantly reduced after daptomycin application. We had no mortality and wound healing was successfully achieved in all patients. Treatment of DSWI due to gram-positive organisms
