Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery. | Emiroglu et al. Journal of Cardiothoracic Surgery 2011 6 120 http content 6 1 120 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery 2 w I- 3 2 3 s f 2 2 Ozan Emiroglu 1 Serkan Durdu Yonca Egin Ahmet R Akar Yesim D Alakoc Cagin Zaim Umit Ozyurda and Nejat Akar3 Abstract Background Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms SNP affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery CABG . Methods A total of 220 patients undergoing first-time CABG between January 2005 and May 2008 were screened for factor V gene G1691A FVL prothrombin factor II G20210A PT G20210A angiotensin I-converting enzyme insertion deletion ACE-ins del polymorphisms by PCR and Real Time PCR. End points were defined as death myocardial infarction stroke postoperative bleeding respiratory and renal insufficiency and event-free survival. Patients were compared to assess for any independent association between genotypes for thrombosis and postoperative phenotypes. Results Among 220 patients the prevalence of the heterozygous FVL mutation was n 24 and n 8 were heterozygous carriers of the PT G20210A mutation. Genotype distribution of ACE-ins del was and in genotypes I I I D and D D respectively. FVL and PT G20210A mutations were associated with higher prevalence of totally occluded coronary arteries p . Furthermore the risk of left ventricular aneurysm formation was significantly higher in FVL heterozygote group compared to FVL G1691G p . ACE D D genotype was associated with hypertension p peripheral vascular disease p and previous myocardial
