Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí yhọc Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice. | Journal of Brachial Plexus and Peripheral Nerve Injury BioMed Central Open Access Short report Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice Prasanna Kumar T Subbanna C G Prasanna Bhagawat K Gunale and Manoj GTyagi Address Department of Pharmacology Clinical Pharmacology Christian Medical College Vellore-632002 India Email Prasanna Kumar T Subbanna - drprasannats@ C G Prasanna - drprasannacg@ Bhagawat K Gunale - ManojGTyagi - tyagi243@ Corresponding author Published 4 February 2007 Received 4 December 2006 Journal of Brachial Plexus and Peripheral Nerve Injury 2007 2 3 doi 1749-7221 -2- Accepted 4 February 2007 3 This article is available from http content 2 1 3 2007 Subbanna et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Cyclin-dependent kinase 5 CDK-5 appears to play a significant role in peripheral nerve regeneration as CDK-5 inhibition retards nerve regeneration following nerve crush. Antiinflammatory drug acetyl salicylic acid elevates CDK-5 and reduces ischemia - reperfusion injury in cultured neurons. In this study we have evaluated the effect of acetyl salicylic acid on functional recovery following sciatic nerve crush in mice. Eighteen Swiss albino mice underwent unilateral sciatic nerve crush. Test animals received acetyl salicylic acid 100 mg kg day n 6 or 50 mg kg day n 6 and control animals n 6 received normal saline for 14 days following surgery. Functional recovery was assessed with improvement in Sciatic Function Index nociception and gait. In comparison with normal saline treatment acetyl salicylic acid 100 mg kg day significantly improved functional recovery following .
