Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Initial experience with a synthetic sealant PleuraSeal™ after pulmonary resections: a prospective study with retrospective case matched controls. | Dango et al. Journal of Cardiothoracic Surgery 2010 5 50 http content 5 1 50 JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Initial experience with a synthetic sealant PleuraSeal after pulmonary resections a prospective study with retrospective case matched controls Sebastian Dango 1 Rong Lin2 Ellen Hennings1 and Bernward Passlick1 Abstract The objective of this study was to evaluate postoperative outcome and efficacy of a hydrogel tissue sealant for prevention of alveolar leakage after open lung resections. 20 consecutive patients were enrolled in the PleuraSeal sealant group PSG and case matched with 20 retrospective controls CG with standard treatment. Assessment of postoperative air leakage was performed until chest tube removal. Patients were followed until 30 days after discharge. At end of surgery 100 in the PSG and 0 in the CG were air leak free p . Duration of postoperative chest tube suction was shorter in PSG p and air leak chest tube was removed earlier p . Limitation for chest tube removal due to a pulmonary leak was 35 in CG and 5 in PSG p . Patients remaining air leak free thru discharge was 95 and 15 for PSG and CG p . The study demonstrated a superior efficacy of PleuraSeal sealant compared with standard surgical treatment for sustained sealing of postoperative air leakage and causes shorter air leak chest tube duration. Introduction Postoperative air leakage remains the most common pulmonary complication in patients undergoing pulmonary resection with a reported occurrence of 18-58 of the cases 1 2 . Persistent postoperative air leakage 7 days has been reported in up to 25 of patients undergoing pulmonary resection 3 . Described risk factors for pulmonary leakage are incomplete fissures 4 underlying lung diseases such as emphysema fibrosis tuberculosis or malignancies 5 presence of a lymphangioleiomyo-matosis 5 intrathoracic adhesions 6 older patients 75 years 7 and lower .
