Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Roles of planar cell polarity pathways in the development of neutral tube defects. | Wu et al. Journal of Biomedical Science 2011 18 66 http content 18 1 66 The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE REVIEW Open Access Roles of planar cell polarity pathways in the development of neutral tube defects Gang Wu1 2 Xupei Huang2 Yimin Hua1 and Dezhi Mu1 3 Abstract Neural tube defects NTDs are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs the fundamental etiology for the majority of cases of NTDs remains unclear. Planar cell polarity PCP signaling pathway which is important for polarized cell movement such as cell migration and organ morphogenesis through the activation of cytoskeletal pathways has been shown to play multiple roles during neural tube closure. The disrupted function of PCP pathway is connected with some NTDs. Here we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs. Keywords Neural tube defects planar cell polarity organ morphogenesis signaling pathway Background Neural tube defects NTDs arise when the neural tube the embryonic precursor of the brain and spinal cord fails to close during neurulation. Defects in neural tube closure are the second most c ommon human birth defects after congenital heart defects 1 . Recent birth prevalence estimates show that NTDs account for per 1000 in the United States during 2001-2004 1 to per 1000 in Western Australia during 2001-2006 and per 1000 in Iran during 1998-2005 while prevalence in Shanxi a province in North China reach to per 1000 during 2002-2004 2 . The cranial region anencephaly or the low spine open spina bifida and myelomeningocele are most commonly affected 3 . NTDs affecting the brain are invariably lethal perinatally whereas open spina bifida is compatible with postnatal survival but frequently results in serious
