Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy. | Milani et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2010 5 11 http content 5 1 11 JOURNAL OF BRACHIAL PLEXUS AND PERIPHERAL NERVE INJURY METHODOLOGY Open Access Progesterone - new therapy in mild carpal tunnel syndrome Study design of a randomized clinical trial for local therapy Paolo Milan 1 2 3 Mauro Mondelli4 Federica Ginanneschi1 Riccardo Mazzocchio1 and Alessandro Rossi1 Abstract Background Local corticosteroid injection for carpal tunnel syndrome CTS provides greater clinical improvement in symptoms one month after injection compared to placebo but significant symptom relief beyond one month has not been demonstrated and the relapse of symptoms is possible. Neuroprotection and myelin repair actions of the progesterone was demonstrated in vivo and in vitro study. We report the design of a randomized controlled trial for the local injection of cortisone versus progesterone in mild idiopathic CtS. Methods Sixty women with age between 18 and 60 years affected by mild idiopathic CTS diagnosed on the basis of clinical and electrodiagnostic tests will be enrolled in one centre. The clinical electrophysiological and ultasonographic findings of the patients will be evaluate at baseline 1 6 and 12 months after injection. The major outcome of this study is to determine whether locally-injected progesterone may be more beneficial than cortisone in CTS at clinical levels tested with symptoms severity self-administered Boston Questionnaire and with visual analogue pain scale. Secondary outcome measures are duration of experimental therapy improvement of electrodiagnostic and ultrasonographic anomalies at various follow-up comparison of the beneficial and harmful effects of the cortisone versus progesterone. Conclusion We have designed a randomized controlled study to show the clinical effectiveness of local progesterone in the most frequent human focal peripheral mononeuropathy and to demonstrate the neuroprotective effects of the .
