Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Possible roles of Epstein-Barr virus in Castleman disease. | Journal of Cardiothoracic Surgery BioMed Central Research article Open Access Possible roles of Epstein-Barr virus in Castleman disease Chih-Hao Chen 1 3 Hung-Chang Liu1 3 Tzu-Ti Hung1 3 and Tsang-Pai Liu 2 3 Address Department of Thoracic Surgery Mackay Memorial Hospital Taipei City Taiwan 2Department of General Surgery Mackay Memorial Hospital Taipei City Taiwan and 3Mackay Medicine Nursing and Management College Taipei County Taiwan Email Chih-Hao Chen - musclenet2003@ Hung-Chang Liu - oncoteam@ Tzu- Ti Hung - tzdi0921731610@ Tsang-Pai Liu - liutp@ Corresponding author Published 9 July 2009 Received 18 April 2009 Journal of Cardiothoracic Surgery 2009 4 31 doi 1749-8090-4-31 Accepted 9 July 2009 This article is available from http content 4 1 31 2009 Chen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Complete resection seemed to be curative in patients with Castleman disease of any location but the disease is likely to be reactive in its pathogenesis. The relation between Epstein-Barr virus and Castleman disease has not been elucidated. We tried to define the role of Epstein-Barr virus in the pathogenesis of Castleman disease. Methods 20 cases of Castleman disease were retrospectively reviewed from 1993 to 2006. At least 2 to 4 representative sections of formalin-fixed paraffin-embedded specimens from each patient were obtained to examine the presence of EBV and its localization by hematoxylin-eosin stain immunohistochemistry polymerase chain reaction and In-situ hybridization Results Hyaline-vascular type was diagnosed in 18 cases plasma cell type in 1 and mixed type in 1 case. All of them were positive for .
