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báo cáo khoa học: "Two successful pregnancies in a woman with chronic myeloid leukemia exposed to nilotinib during the first trimester of her second pregnancy: case study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Two successful pregnancies in a woman with chronic myeloid leukemia exposed to nilotinib during the first trimester of her second pregnancy: case study | BioMed Central Journal of Hematology Oncology Open Access Case study Two successful pregnancies in a woman with chronic myeloid leukemia exposed to nilotinib during the first trimester of her second pregnancy case study Monika Conchon 1 Sabri S Sanabani2 Israel Bendit1 Fernanda Maria Santos2 Mariana Serpa1 and Pedro Enrique Dorliac-Llacer1 Address Department of Hematology Faculty of Medicine University of São Paulo São Paulo Brazil and 2Fundaẹão Pro-Sangue Hemocentro de São Paulo Brazil Email Monika Conchon - conchon@uol.com.br Sabri S Sanabani - sabyem_63@yahoo.com Israel Bendit - isbendit@usp.br Fernanda Maria Santos - fferhot@hotmail.com Mariana Serpa - marianaserpa@hotmail.com Pedro Enrique Dorliac-Llacer - llacer.ops@terra.com.br Corresponding author Published 6 October 2009 Received 17 September 2009 Journal of Hematology Oncology 2009 2 42 doi 10.1186 1756-8722-2-42 Accepted 6 October 2009 This article is available from http www.jhoonline.org content 2 1 42 2009 Conchon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ The occurrence of chronic myeloid leukemia in pregnancy is rare and its management poses a clinical challenge for physicians treating these patients. We report a 30-year-old woman with chronic myeloid leukemia who became pregnant twice successfully. Philadelphia-positive CML in its chronic phase was diagnosed at 16 weeks of her first gestation. At that time she received no treatment throughout her pregnancy. At 38 weeks of gestation a normal infant was delivered by cesarean section. At six weeks postpartum the patient underwent imatinib mesylate therapy but she could not tolerate the treatment. The treatment