Đang chuẩn bị liên kết để tải về tài liệu:
báo cáo hóa học:" Hypothetical membrane mechanisms in essential tremor"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Hypothetical membrane mechanisms in essential tremor | Journal of Translational Medicine BioMed Central Open Access Hypothetical membrane mechanisms in essential tremor Aasef G Shaikh 1 Kenichiro Miura5 Lance M Optican2 Stefano Ramat3 Robert M Tripp4 and David S Zee1 Address Department of Neurology The Johns Hopkins University Baltimore MD USA 2National Eye Institute National Institutes of Health Bethesda MD USA 3University of Pavia Pavia Italy 4FlexAble Systems Fountain Hills AZ USA and 5Graduate School of Medicine Kyoto University Kyoto Japan Email Aasef G Shaikh - ashaikh@dizzy.med.jhu.edu Kenichiro Miura - kmiura@brain.med.kyoto-u.ac.jp Lance M Optican - lanceoptican@nih.gov Stefano Ramat - steram@bioing.unipv.it Robert M Tripp - bob@flexable.com David S Zee - dzee@dizzy.med.jhu.edu Corresponding author Published 6 November 2008 Received 15 July 2008 Accepted 6 November 2008 Journal of Translational Medicine 2008 6 68 doi 10.1186 1479-5876-6-68 This article is available from http www.translational-medicine.com content 6 1 68 2008 Shaikh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Essential tremor ET is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Specifically we propose that neural circuits controlling ballistic movements are inherently unstable due to their underlying reciprocal innervation. Such instability is enhanced by increased neural membrane excitability and the circuit begins to oscillate. These oscillations manifest as tremor. Methods Postural limb tremor was recorded in 22 ET patients and then the phenotype was simulated with a conductance-based neuromimetic model of ballistic movements. The model .