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Investigation of clinical, paraclinical symptoms and converted prevalence to carcinoma of sinonasal inverted papilloma patients

To investigate the sinonasal inverted papilloma clinical, paraclinical symtoms and prevalence of inverted papilloma conveted to carcinoma. A crosssectional study was carried on 81 subjects with sinonasal inverted papilloma. Data of main clinical, paraclinical symptoms (endoscopy and histopathology data) were collected and analyzed by independent - sample t-test or Pearson’s χ 2 test or Fisher’s exact test. | Journal of military pharmaco-medicine no7-2018 INVESTIGATION OF CLINICAL, PARACLINICAL SYMPTOMS AND CONVERTED PREVALENCE TO CARCINOMA OF SINONASAL INVERTED PAPILLOMA PATIENTS Nguyen Ba Khoa*; Ho Anh Son**; Do Tram Anh*** Nguyen Thi Ngoc Dung*; Nguyen Linh Toan** SUMMARY Objectives: To investigate the sinonasal inverted papilloma clinical, paraclinical symtoms and prevalence of inverted papilloma conveted to carcinoma. Subjects and method: A crosssectional study was carried on 81 subjects with sinonasal inverted papilloma. Data of main clinical, paraclinical symptoms (endoscopy and histopathology data) were collected and 2 analyzed by independent - sample t-test or Pearson’s χ test or Fisher’s exact test. Results: The main symptoms of inverted papilloma patient were nose obstruction (96.5%); runny nose (42%); headache occurred in 38.3% of patients. Nose bleeding occurred in 13.6% of patients with statistically significant differences between male and female (p < 0.05). In 81 inverted papilloma patients, 16%; 17.3% and 8.6% of them had a history of smoking; alcohol consumption and allergy, respectively. Stage T3 was predominant in inverted papilloma patients (37%). Other stages, T2, T4 and T1 were 28.4; 24.7 and 9.9%, respectively. The recurrent rate of inverted papilloma was 28.4%; malignant transformation rate was 10.5%. Conclusion: Inverted papilloma is poor in symptom but rich in recurrence and malignant transformation rate. * Keywords: Sinonasal inverted papilloma; Clinical, paraclinical symptoms. INTRODUCTION Sinonasal inverted papilloma (IP) is a benign and relatively rare tumor of the nasal cavity and paranasal sinuses, that usually originates in the nasal mucosa and nasal sinus wall. This disease has been documented in the literature for more than a century, but so far, IP is still a matter of debate due to the complex nature of the disease, the high prevalence of recurrence. and the coordination with the cancer. With an incidence between 0.2 and 1.5 cases