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Fluid resuscitation guided by stroke volume variation in septic shock

This study was done to evaluate fluid resuscitation guided by stroke volume variation in septic shock. This prospective randomized included sixty patients presented with hypotension (MAP less than 65 mmHg) and hyperlactatemia (serum lactate above 2 mmol/L) in intensive care unit (ICU). Patients were randomly classified into two groups, 30 patients for each group; group I (Early-goal-directed-therapy group {EGDT}) and group II (stroke volume variation guided fluid resuscitation). In group I mortality rate was 33.33% in comparison to 23.33% in group II with no statistically significant difference between two groups. As regard SOFA score, there was statistically significant decrease in 72 hours SOFA score in group II than in group I. Comparing fluid given between two groups showed highly significant increase in amount of fluid in group I than group II. Incorporation of echocardiography early in management of septic shock patients resulted in decrease in the amount of fluid and decrease useless administration of inotropes, early administration of inotropes after assessment of cardiac function by echocardiography which could help in improvement of septic shock outcomes and early vasopressor administration. | Fluid resuscitation guided by stroke volume variation in septic shock