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P38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice

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There is a need for agents that suppress inflammation and progression of chronic obstructive pulmonary disease. p38 mitogen-activated protein kinase (p38 MAPK) has been associated with this disorder, and several inhibitors of this cascade are in clinical trials for its treatment, but their efficacy and utility are unknown. |