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A comprehensive survey of the mutagenic impact of common cancer cytotoxics

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Genomic mutations caused by cytotoxic agents used in cancer chemotherapy may cause secondary malignancies as well as contribute to the evolution of treatment-resistant tumour cells. The stable diploid genome of the chicken DT40 lymphoblast cell line, an established DNA repair model system, is well suited to accurately assay genomic mutations. |

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A comprehensive survey of the mutagenic impact of common cancer cytotoxics
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