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Báo cáo y học: "Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair. | Available online http arthritis-research.eom content 11 3 R74 Open Access Research article Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation implications for cartilage repair Pascale Simard1 2 Hugo Galarneau1 Sébastien Marois1 Daniel Rusu1 3 Caroline D Hoemann4 Patrice E Poubelle1 3 Hani El-Gabalawy5 and Maria JG Fernandes1 2 1Centre de Recherche en Rhumatologie et Immunologie Centre de Recherche du CHUQ-CHUL boul. Laurier Québec G1V 4G2 Canada 2Department of Anatomy and Physiology Université Laval avenue de la Médecine Québec G1V 0A6 Canada 3Department of Medicine Université Laval avenue de la Médecine Québec G1V 0A6 Canada 4Department of Chemical Engineering Institute of Biomedical Engineering Ecole Polytechnique boul. Édouard-Montpetit Montréal H3C 3A7 Canada 5Arthritis Centre University of Manitoba Sherbrook Street Winnipeg R3A 1M4 Canada Contributed equally Corresponding author Maria JG Fernandes maria.fernandes@crchul.ulaval.ca Received 22 Sep 2008 Revisions requested 17 Nov 2008 Revisions received 23 Feb 2009 Accepted 21 May 2009 Published 21 May 2009 Arthritis Research Therapy 2009 11 R74 doi 10.1186 ar2703 This article is online at http arthritis-research.com content 11 3 R74 2009 Simard et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Osteoarthritis is characterized by the progressive destruction of cartilage in the articular joints. Novel therapies that promote resurfacing of exposed bone in focal areas are of interest in osteoarthritis because they may delay the progression of this disabling disease in patients who develop focal lesions. Recently the addition of 80 deacetylated chitosan to cartilage microfractures was shown to promote the