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Báo cáo y học: "Association of lipid peroxidation with hepatocellular injury in preterm infan"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Association of lipid peroxidation with hepatocellular injury in preterm infant. | Available online http ccforum.eom content 6 6 521 Research Open Access Association of lipid peroxidation with hepatocellular injury in preterm infants Barry Weinberger1 Kazimierz Watorek1 Richard Strauss2 Gisela Witz3 Mark Hiatt1 and Thomas Hegyi1 1 Neonatologist University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School New Brunswick NJ USA 2Gastroenterologist University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School New Brunswick NJ USA 3Professor of Environmental and Community Medicine University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School New Brunswick NJ USA Correspondence Barry Weinberger barryw@pol.net Received 2 January 2002 Revisions requested 26 February 2002 Revisions received 20 June 2002 Accepted 7 August 2002 Published 21 August 2002 Critical Care 2002 6 521-525 DOI 10.1186 cc1547 This article is online at http ccforum.com content 6 6 521 2002 Weinberger et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This article is published in Open Access verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Introduction We wished to determine whether cholestasis induced by total parenteral nutrition TPN in preterm newborn infants is associated with increased oxidative stress secondary to increased reactive oxygen intermediates. We hypothesized that elevated urinary barbituric-acid-reacting substances TBARS a marker of oxidative stress would be associated with hepatocellular injury as measured by serum alanine transaminase ALT and aspartate transaminase AST levels. Materials and methods Preterm infants 35 weeks gestation admitted to the neonatal intensive care unit were enrolled with their parents informed consent in either the cholestasis group if their direct bilirubin was 2mg dl 34.2 ựmol l and duration of TPN

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