Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports | Sountoulides et al. Journal of Medical Case Reports 2011 5 429 http content 5 1 429 REVIEW JOURNALOF medical Ur Case REPORTS Open Access Atypical presentations and rare metastatic sites of renal cell carcinoma a review of case reports Petros Sountoulides1 Linda Metaxa2 and Luca Cindolo3 Abstract Renal cell carcinoma is a potentially lethal cancer with aggressive behavior and a propensity for metastatic spread. Due to the fact that the patterns of metastases from renal cell carcinomas are not clearly defined there have been several reports of cases of renal cell carcinoma associated with rare metastatic sites and atypical presenting symptoms. The present review focuses on these atypical rare clinical presentations of renal cell carcinomas both at the time of diagnosis of the primary tumor but also in the years after radical nephrectomy. Introduction Renal cell carcinoma RCC is a lethal tumor that accounts for approximately 3 of all adult malignancies and is associated with approximately 13 000 deaths annually 1 . The introduction and widespread use of sophisticated imaging modalities has resulted in a significant increase in the incidental detection of kidney tumors. Nowadays more than 70 of all renal cancer cases are screen detected as incidental findings on imaging studies obtained for unrelated reasons 2 . Therefore the classical teaching that renal cancer presents with signs and symptoms such as hematuria flank pain and palpable mass is more of the exception rather than the rule. This trend has also resulted in a significant shift in the staging of renal cancer since lesser cases initially present with advanced metastatic disease and more cases of renal tumors are confined to the kidney at the time of diagnosis. Still renal cancers have a strong tendency to metastasize following occasionally unpredictable patterns of spread. There have been several reports of late metastases from RCC even decades after potentially curative surgical .
