Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Brain microischemic phenomena in a woman receiving bevacizumab treatment: a case report. | Quattrocchi et al. Journal of Medical Case Reports 2011 5 84 http content 5 1 84 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Brain microischemic phenomena in a woman receiving bevacizumab treatment a case report 1 2 -3 1 1 Carlo C Quattrocchi Andrea M Alexandre Giuseppe Tonini Yuri Errante Rosario F Grasso Bruno Beomonte Zobel1 Abstract Introduction Several adverse events have been associated with the use of bevacizumab during the treatment of neoplasms such as colorectal cancer breast cancer non-small cell lung cancer pancreatic cancer and renal cell carcinoma. The present case demonstrates how focal neurological symptoms lead to the magnetic resonance imaging-based differential diagnosis between focal parenchymal metastases and microischemic phenomena with crucial implications for patient management. Case presentation We describe the case of a 37-year-old Italian Caucasian woman with metastatic colon cancer who developed focal neurological symptoms during a chemotherapy regimen involving the use of bevacizumab. Brain magnetic resonance imaging examination revealed millimetric lesions with restricted diffusion without perilesional edema or contrast enhancement after gadodiamide intravenous injection suggestive of acute microischemic phenomena. This complication is very rare but clinically significant. Conclusion The differential diagnosis in patients with cancer undergoing bevacizumab treatment should include microischemic phenomena. Introduction We describe the case of a patient with metastatic colon cancer who developed focal neurological symptoms during a chemotherapy regimen including bevacizumab. Some millimetric lesions were detected by a first magnetic resonance imaging MRI examination and were not detectable on the MRI examination performed six months later. In patients with cancer undergoing bevaci-zumab treatment the occurrence of neurological focal symptoms leads to an MRI differential diagnosis between focal .
