Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Acquired A amyloidosis from injection drug use presenting with atraumatic splenic rupture in a hospitalized patient: a case report | Roll et al. Journal of Medical Case Reports 2011 5 29 http content 5 1 29 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Acquired A amyloidosis from injection drug use presenting with atraumatic splenic rupture in a hospitalized patient a case report 1 1 1 2 3 4 Garrett R Roll Andrew Y Lee Kayvan Royaie Brendan Visser Douglas K Hanks Margaret M Knudson Frederick J Roll5 Abstract Introduction Little is known about splenic rupture in patients who develop systemic acquired A amyloidosis. This is the first report of a case of atraumatic splenic rupture in a patient with acquired A amyloidosis from chronic injection drug use. Case presentation A 58-year-old Caucasian man with a long history of injection drug use hospitalized for infective endocarditis experienced atraumatic splenic rupture and underwent splenectomy. Histopathological and microbiological analyses of the splenic tissue were consistent with systemic acquired A amyloidosis most likely from injection drug use that led to splenic rupture without any recognized trauma or evidence of bacterial embolization to the spleen. Conclusion In patients with chronic inflammatory conditions including the use of injection drugs who experience acute onset of left upper quadrant pain the diagnosis of atraumatic splenic rupture must be considered. Introduction Atraumatic splenic rupture ASR can be caused by neoplastic diseases hematological disorders infection and chronic inflammatory states 1 . Patients who are hospitalized rarely experience ASR which carries a mortality of approximately 12 1 . ASR from amyloidosis has been documented previously in three case reports but no patients with chronic injection drug use as the etiological factor in the development of systemic acquired A AA amyloidosis have been described 2-5 . We report the case of a hospitalized patient who experienced atraumatic splenic rupture from acquired systemic AA amyloidosis most likely resulting from chronic .
