Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. | Mossberg et al. Journal of Inflammation 2010 7 40 http content 7 1 40 JOURNAL OF INFLAMMATION RESEARCH Open Access Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome 11 13 2 2 Natalia Mossberg Oluf Andersen Magnus Nordin Staffan Nilsson Ake Svedhem Tomas Bergstrom Kristoffer Hellstrand 2 Charlotta Movitz2 Abstract Background The recurrent Guillain-Barré syndrome RGBS is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS we reported that the magnitude of oxygen radical production respiratory burst in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe fMLF Trp-Lys-Tyr-Met-Val-Met-NH2 WKYMVM or phorbol myristate acetate PMA and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results Disease severity assessed using the MRC score was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM p and respectively n 10 . Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF p or WKYMVM p . Conclusion We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS. Introduction The recurrent Guillain-Barré syndrome RGBS is a demyelinating disease of the peripheral nervous system characterized by episodes of relapsing and remitting symptoms with complete or near complete functional recovery between episodes 1-3 . Each episode fulfils the diagnostic criteria for GBS including symmetric limb weakness and decreased or absent muscle reflexes or Miller Fisher syndrome 4 5 . The respiratory burst in human phagocytes is a pivotal anti-microbial effector function of .
