HANDBOOK OF THE CHEMICAL RISK ASSESSMENT Health Hazards to Humans, Plants, and Animals ( VOLUME 1 ) - PART 6

Sodium monofluoroacetate (CH2FCOONa), còn được gọi là 1080 hoặc 1080 Compound, thuộc về một lớp hóa chất được biết đến như fluoroacetates (Pattison 1959). Nó là một nước hòa tan, không vị và không có mùi độc hại của tiềm năng phi thường đã được sử dụng rộng rãi đối với các loài gặm nhấm và các loài gây hại động vật có vú khác (Anonymous 1946, Negherbon 1959; Rammell và Fleming 1978, McIlroy 1981a; Hornshaw et al 1986;. Aulerich et al 1987 Connolly và Burns năm 1990; Eisler 1995). . | CHAPTER 26 Sodium Monofluoroacetate Compound 1080 INTRODUCTION Sodium monofluoroacetate CH2FCOONa also known as 1080 or Compound 1080 belongs to a class of chemicals known as the fluoroacetates Pattison 1959 . It is a tasteless and odorless water-soluble poison of extraordinary potency that has been used widely against rodents and other mammalian pests Anonymous 1946 Negherbon 1959 Rammell and Fleming 1978 McIlroy 1981a Hornshaw et al. 1986 Aulerich et al. 1987 Connolly and Burns 1990 Eisler 1995 . The widespread use of 1080 in pest control has resulted in accidental deaths of livestock wildlife pets cats and dogs and humans Anonymous 1946 Chenoweth 1949 Sayama and Brunetti 1952 Negherbon 1959 . Environmental Protection Agency USEPA 1976 McIlroy 1982a and several suicides in Asia from drinking 1080 rat poison solutions Howard 1983 . There is no effective antidote to 1080 Mead et al. 1991 . When consumed fluoroacetate is converted to fluorocitrate inhibiting the enzymes aconitase and succinate dehydrogenase. The accumulated citrate interferes with energy production and cellular function Aulerich et al. 1987 . Monofluoroacetic acid CH2FCOOH was first synthesized in Belgium in 1896 but attracted little attention from chemists and pharmacologists at that time Chenoweth 1949 Atzert 1971 . In 1927 sodium monofluoroacetate was patented as a preservative against moths Sayama and Brunetti 1952 . The toxic nature of monofluoroacetate compounds was first noted in Germany in 1934 Atzert 1971 . In the late 1930s and early 1940s Polish scientists conducted additional research on the toxic properties of fluoroacetate compounds especially on the methyl ester of fluoroacetic acid that they had synthesized Anonymous 1946 Chenoweth 1949 . In 1942 British scientists further refined this compound to the sodium salt which became known as 1080 Anonymous 1946 . In 1944 potassium monofluoroacetate CH2FCOOK was isolated from Dichapetalum cymosium a South African plant and was the .