Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Protein targets of inflammatory serine proteases and cardiovascular disease. | Sharony et al. Journal of Inflammation 2010 7 45 http content 7 1 45 JOURNAL OF INFLAMMATION REVIEW Open Access Protein targets of inflammatory serine proteases and cardiovascular disease 12 2 2 23 . -2 Ram Sharony Pey-Jen Yu Joy Park Aubrey C Galloway Paolo Mignatti Giuseppe Pintucci Abstract Serine proteases are a key component of the inflammatory response as they are discharged from activated leukocytes and mast cells or generated through the coagulation cascade. Their enzymatic activity plays a major role in the body s defense mechanisms but it has also an impact on vascular homeostasis and tissue remodeling. Here we focus on the biological role of serine proteases in the context of cardiovascular disease and their mechanism s of action in determining specific vascular and tissue phenotypes. Protease-activated receptors PARs mediate serine protease effects however these proteases also exert a number of biological activities independent of PARs as they target specific protein substrates implicated in vascular remodeling and the development of cardiovascular disease thus controlling their activities. In this review both PAR-dependent and -independent mechanisms of action of serine proteases are discussed for their relevance to vascular homeostasis and structural functional alterations of the cardiovascular system. The elucidation of these mechanisms will lead to a better understanding of the molecular forces that control vascular and tissue homeostasis and to effective preventative and therapeutic approaches. Introduction Inflammation is a process that delivers defensive tools to injured tissues. Tissue injury implies changes to blood vessels and disruption of normal histological features with rapid recruitment of leukocytes during this process inflammatory mediators coordinate the response in a manner that preserves both vascular integrity and circulation while allowing extravasation of leukocytes . their recruitment from .
