Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles. | Journal of Inflammation BioMed Central Research Open Access The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles Susan K Bortolotto 1 Wayne A Morrison2 and Aurora Messina1 Address 1Bernard O Brien Institute of Microsurgery Fitzroy Street Fitzroy AUSTRALIA and 2Department of Surgery University of Melbourne St. Vincent s Hospital Melbourne Victoria AUSTRALIA Email Susan K Bortolotto - Wayne A Morrison - Aurora Messina - messinaa@ Corresponding author Published 27 September 2004 Received 13 July 2004 Accepted 27 September 2004 Journal of Inflammation 2004 1 2 doi 1476-9255-1 -2 This article is available from http content 1 1 2 2004 Bortolotto et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Ischaemia reperfusion IR injury of skeletal muscle is a significant cause of morbidity following trauma and surgical procedures in which muscle fibre types exhibit different susceptibilities. The relative degree of mast cell mediated injury within different muscle types is not known. Methods In this study we compared susceptibility of the fast-twitch extensor digitorum longus EDL mixed fast slow-twitch gastrocnemius and the predominately slow-twitch soleus muscles to ischemia reperfusion IR injury in four groups of mice that harbour different mast cell densities C57 DBA mast cell depleted Wf Wf their heterozygous Wf and normal littermates and control C57BL 6 mice. We determined whether susceptibility to IR injury is associated with mast cell content and or fibre type and or mouse strain. In experimental groups the hind limbs of mice were subjected to 70 minutes warm .
