Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Mesenchymal stem cells avoid allogeneic rejection. | Journal of Inflammation BioMed Central Review Open Access Mesenchymal stem cells avoid allogeneic rejection Jennifer M Ryan1 Frank P Barry2 J Mary Murphy2 and Bernard P Mahon 1 Address Unstitute of Immunology National University of Ireland Maynooth Co. Kildare Ireland and 2Regenerative Medicine Institute REMEDI National Centre for Biomedical Engineering Science National University of Ireland Galway Ireland Email Jennifer M Ryan - Frank P Barry - J Mary Murphy - Bernard P Mahon - bpmahon@ Corresponding author Published 26 July 2005 Received 01 April 2005 Journal of Inflammation 2005 2 8 doi 1476-9255-2-8 Accepted 26 July 2005 This article is available from http content 2 1 8 2005 Ryan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Adult bone marrow derived mesenchymal stem cells offer the potential to open a new frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of conditions associated with damaged cartilage bone muscle tendon and ligament. However the normal process of immune rejection of mismatched allogeneic tissue would appear to prevent the realisation of such ambitions. In fact mesenchymal stem cells avoid allogeneic rejection in humans and in animal models. These finding are supported by in vitro co-culture studies. Three broad mechanisms contribute to this effect. Firstly mesenchymal stem cells are hypoimmunogenic often lacking MHC-II and costimulatory molecule expression. Secondly these stem cells prevent T cell responses indirectly through modulation of dendritic cells and directly by disrupting NK as well as CD8 and CD4 T cell function. .
