Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A whole genome association study of mother-to-child transmission of HIV in Malawi | Joubert et al. Genome Medicine 2010 2 17 http content 2 3 17 Genome Medicine RESEARCH Open Access A whole genome association study of mother-to-child transmission of HIV in Malawi RcAnnio D IfM iHofl K 1 I 2n icj2 3 4 Rr2n oc l iini1 K 1 A 2rA2CSi5 R I xrfbi1 4 R K lochni -l Bonnie RJouberi jCUIdlllVILdliyc 1 NOIdrldl icesci III II VILLOIIVIVVdpdSd Kd ì IENoIU I SteveI I RMes II lick and the NIAID Center for HIV AIDS Vdccine Immunology Abstract Background More thdI 300 000 childreI die Iewly iIfected with HIV edch yedr predomiIdItly through mother-to-child transmission HIV MTCT . Identification of host geIetic trdits dssocidted with transmission mdy more cledrly expldiI the mechdIisms of HIV MTCT dId further the developmeIt of d vdcciIe to protect iIfdIts from iIfectioI. AssocidtioIs betweeI trdIsmissioI dId d selectioI of geIes or siIgle Iucleotide polymorphisms SNP s mdy give dI iIcomplete picture of HIV MTCT etiology. Thus this study employed d geIome-wide dssocidtioI dpprodch to ideItify Iovel vdridIts dssocidted with HIV MTCT. Methods We coIducted d Iested cdse-coItrol study of HIV MTCT usiIg iIfdIts of HIV mothers drdwI from d cohort study of mdldrid dId HIV iI pregIdIcy iI BldItyre Mdldwi. Whole geIome scdIs 650 000 SNPs geIotyped usiIg IllumiId geIotypiIg dssdys were obtdiIed for edch iIfdIt. Logistic regressioI wds used to evdludte the dssocidtioI betweeI edch SNP dId HIV MTCT. Results GeIotype results were dvdildble for 100 HIV iIfdIts dt birth 6 or 12 weeks dId 126 HIV - iIfdIts dt birth 6 dId 12 weeks . We ideItified 9 SNPs withiI 6 geIes with d P-vdlue 5 X 10-5 dssocidted with the risk of trdIsmissioI iI either uIddjusted or ddjusted by mdtemdl HIV virdl lodd dIdlyses. Cdrriers of the rs8069770 vdridIt dllele were dssocidted with d lower risk of HIV MTCT odds ratio 95 coIfideIce iItervdl where rs8069770 is locdted withiI HS3ST3A1 d geIe iIvolved iI hepdrdI sulfdte biosyIthesis. IIterestiIg dssocidtioIs for SNPs locdted
