Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1-patient exposed to efavirenz for three weeks: a case report and review of the literature | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1-patient exposed to efavirenz for three weeks a case report and review of the literature Pnnin Polilli1 p rrnfi2 T iiarìCì C oe TitiTio1 í t7ỈM2 J. nn u U-StL cHI XL la. Us Ll ILU l J tel lUa ko U S-l o Annalisa Saracino3 Augusta Consorte2 Gioacchino Angarano3 Francesco Di Masi2 Elena Mazzotta2 and Paolo Fazii2 Addresses 1Clinical Pathology Unit Ospedale Civile Spirito Santo Via Fonte Romana 8 65124 Pescara Italy 2Infectious Disease Unit Ospedale Civile Spirito Santo Via Fonte Romana 8 65124 Pescara Italy 3Infectious Disease Department University of Foggia Ospedali Riuniti Via L. Pinto 1 71100 Foggia Italy Email EP - GP - parruti@ LC - FS - phoede@ AS - AC - GA - FDM - francescodimasi@ EM - PF - Corresponding author Received 16 May 2008 Accepted 8 May 2009 Published 18 September 2009 Journal of Medical Case Reports 2009 3 9132 doi 1752-1947-3-9132 This article is available from http jmedicalcasereports article view 9132 2009 Polilli et al. licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Selection of the K103N mutation is associated with moderately reduced in vitro fitness of HIV. Strains bearing K103N in vivo tend to persist even in the absence of additional drug pressure as minority quasispecies often undetectable in genotyping resistance testing assays performed at standard conditions. Here we report on the rapid and long lasting .
