Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: No association between COMT val158met polymorphism and suicidal behavior: metaanalysis and new data | Tovilla-Zárate et al. BMC Psychiatry 2011 11 151 http 1471 -244X 11 151 BMC Psychiatry RESEARCH ARTICLE Open Access No association between COMT val158met polymorphism and suicidal behavior metaanalysis and new data 1 2 1 3 4 Carlos Tovilla-Zárate Isela Juárez-Rojop Teresa Ramon-Frias Mario Villar-Soto Sherezada Pool-García Beatriz Camarena Medellín5 Alma D Genis Mendoza6 Lilia López Narvaez7 and Nicolini Humberto6 Abstract Background The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a metaanalysis. Methods We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently we performed a meta-analysis of published genetic association studies by searching through Medline PubMed and Web of Science databases. Results No significant differences were found in the distribution of alleles 2 1 df p or genotypes 2 2 df p . The meta-analysis comprising 12 association studies including the present one showed that the risk COMTmet allele of COMTval158 met is not associated with suicidal behavior OR 95 CI even in the absence of heterogeneity OR 95 CI . Conclusion Our results showed no association between COMTval158 met and suicidal behavior. However more studies are necessary to determine conclusively an association between COMT and suicidal behavior. Background Suicidal behavior is a major health problem worldwide. Suicide has been suggested to involve catecholaminergic dysfunction and to have a genetic correlate. Many significant abnormalities in catecholaminergic dysfunction have been identified in suicide .
