Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection | Mohamadkhani et al. Virology Journal 2010 7 228 http content 7 1 228 VIROLOGY JOURNAL RESEARCH Open Access The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection 1 2 1 1 1 Ashraf Mohamadkhani Kourosh Sayemiri Reza Ghanbari Elham Elahi Hossein Poustchi Ghodratollah Montazeri1 Abstract BACKGROUND The natural history of hepatitis B virus HBV is complex and influenced by the level of viral replication and host factors. The hepatoprotective role of high density lipoproteins HDL and adiponectin as host factors on HBV persistence is less well understood. METHODS To investigate correlation between HBV DNA level with clinical parameters in patients with chronic hepatitis B 92 male subjects with HBV infection without any risk factors for diabetes were enrolled in this study. Age and BMI of the study population were matched and HBV DNA ALT tumor necrosis factor alpha TNF-a adiponectin and lipid levels was measured. RESULTS Serum HBV DNA correlated inversely with serum HDL level r P . The median of log copies ml for HBV DNA was considered as cut off point. Patients with HBV DNA level higher than cut off point had lower adiponectin vs pg ml p . Also adiponectin had a negative correlation with TNF-a r P and positive correlations with HDL r P .Multivariate regression models show that serum HDL level is an independed factor to predict serum HBV DNA. CONCLUSION Our findings showed that higher HBV DNA levels are associated with lower HDL and adiponectin but induced TNF-alpha values. Introduction The broad outcomes of hepatitis B virus HBV infection can be divided into acute infection and chronic hepatitis 1 . The ongoing replication of HBV in chronic hepatitis induce oxidative stress and associated with liver inflammation which over the course of years increases risk of fibrosis cirrhosis and liver cancer 2 3 . Factors which determine viral replication and
