Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic characterization of wild-type measles viruses isolated in China, 2006-2007 | Ji et al. Virology Journal 2010 7 105 http content 7 1 105 VIROLOGY JOURNAL RESEARCH Open Access Genetic characterization of wild-type measles viruses isolated in China 2006-2007 Yixin Ji 1 Songtao Xu1 Yan Zhang1 Zhen Zhu1 Naiying Mao1 Xiaohong Jiang1 Chao Ma2 Peishan Lu3 Changyin Wang4 Yong Liang5 Huanying Zheng6 Yang Liu7 Defang Dai8 Lei Zheng9 Jianhui Zhou10 Shuang Wang10 Zhenying Zhang11 Shengwei Wu12 Lijuan Nan13 Li Li2 Xiaofeng Liang2 David Alexander Featherstone14 Paul A Rota15 William J Bellini15 and Wenbo Xu 1 Abstract Molecular characterization of wild-type measles viruses in China during 1995-2004 demonstrated that genotype H1 was endemic and widely distributed throughout the country. H1-associated cases and outbreaks caused a resurgence of measles beginning in 2005. A total of 210 094 measles cases and 101 deaths were reported by National Notifiable Diseases Reporting System NNDRS and Chinese Measles Laboratory Network LabNet from 2006 to 2007 and the incidences of measles were 100 000 population and 100 000 population in 2006 and 2007 respectively. Five hundred and sixty-five wild-type measles viruses were isolated from 24 of 31 provinces in mainland China during 2006 and 2007 and all of the wild type virus isolates belonged to cluster 1 of genotype H1. These results indicated that H1-cluster 1 viruses were the predominant viruses circulating in China from 2006 to 2007. This study contributes to previous efforts to generate critical baseline data about circulating wild-type measles viruses in China that will allow molecular epidemiologic studies to help measure the progress made toward China s goal of measles elimination by 2012. Introduction Measles virus MeV is a single-stranded negative-sense RNA virus belonging to the genus Morbillivirus family Paramyxoviridae order Mononegavirales. Measles is a vaccine-preventable disease but is still a major killer of infants worldwide. During 2000-2008 global measles mortality declined
