Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target | Journal of Translational Medicine BioMed Central Open Access Angiostatin anti-angiogenesis requires IL-12 The innate immune system as a key target Adriana Albini 41 Claudio BrigatC2 Agostina Ventura3 Girieca Lorusso1 4 Marta Pinter4 Monica Morini2 Alessandra Mancino5 Antonio Sica5 6 and Douglas M Noonan1 4 Address 1Polo Scientifico e Tecnologico IRCCS Multimedica Milan Italy 2Istituto Nazionale per la Ricerca sul Cancro Genova Italy 3Laboratorio di Biologia Vascolare CBA-Centro Biotecnologie Avanzate Genova Italy 4Dipartimento di Scienze Cliniche e Biologiche Università degli Studi dell Insubria Varese Italy 5Laboratorio di Immunologia Molecolare Istituto Clinico Humanitas Milan Italy and 6DISCAFF University of Piemonte Orientale A. Avogadro Novara Italy Email Adriana Albini - Claudio Brigati - claudio_brigati@ Agostina Ventura - venturaa@ Girieca Lorusso - Marta Pinter - pintermarta@ Monica Morini - Alessandra Mancino - Antonio Sica - Douglas M Noonan - Corresponding author fEqual contributors Published 14 January 2009 Received 16 December 2008 _ -T-mno Accepted 14 January 2009 Journal of Translational Medicine 2009 7 5 doi l479-5876-7-5 This article is available from http content 7 1 5 2009 Albini et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Angiostatin an endogenous angiogenesis inhibitor is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo however its direct action on endothelial cells is
