Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles | Journal of Translational Medicine BioMed Central Commentary Translating molecular medicine into clinical tools doomed to fail by neglecting basic preanalytical principles Klaus Jung 1 2 Ferdinando Mannello3 and Michael Lein1 2 Open Access Address Department of Urology Charité - Universitatsmedizin Berlin Campus Mitte Schumannstr. 20 21 10117 Berlin Germany 2Berlin Institute for Urologic Research Berlin Germany and 3Department of Biomolecular Sciences Section of Clinical Biochemistry University Carlo Bo Urbino Italy Email Klaus Jung - Ferdinando Mannello - Michael Lein - Corresponding author Published 14 October 2009 Received 19 August 2009 Journal of Translational Medicine 2009 7 87 doi l479-5876-7-87 Accepted 14 October 2009 This article is available from http content 7 1 87 2009 Jung et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract This commentary discusses a study on measurements of matrix metalloproteinase 9 MMP-9 in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical obstacle to effective translational medicine as previously documented in JTM journal. Although serum has been frequently proven as inappropriate sample for determining numerous circulating MMPs among them MMP-9 there are over and over again studies as in this case that measure MMP-9 in serum. Comparative measurements in serum and plasma samples demonstrated higher concentrations for MMP-9 in serum due to the additional release from leukocytes and platelets following the coagulation fibrinolysis process. From this example it can be concluded that
