Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Genomic aberrations in borderline ovarian tumors | Micci et al. Journal of Translational Medicine 2010 8 21 http content 8 1 21 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Genomic aberrations in borderline ovarian tumors E r I r r I h I I I 11 1 r J N I I s I I z t m 1 I r I ỉ I z t I I I r 2 3 I I Z 1 Z 1 A -J 1 K l A L J I J V4 o J l h s ĨI I r r k 4 6 Francesca Micci Lisoein Haugom Terje Amquist Hege K Andersen Vera M Abeler Ben Davidson Claes G Trope5 Ragnhild A Lothe2 3 Sverre Heim1 6 Abstract Background According to the scientific literature less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH. Methods We report a series of borderline ovarian tumors n 23 analyzed by G-banding and karyotyping as well as high resolution CGH in addition the tumors were analyzed for microsatellite stability status and by FISH for possible 6q deletion. Results All informative tumors were microsatellite stable and none had a deletion in 6q27. All cases with an abnormal karyotype had simple chromosomal aberrations with 7 and 12 as the most common. In three tumors with single structural rearrangements a common breakpoint in 3q13 was detected. The major copy number changes detected in the borderline tumors were gains from chromosome arms 2q 6q 8q 9p and 13q and losses from 1p 12q 14q 15q 16p 17p 17q 19p 19q and 22q. The series included five pairs of bilateral tumors and in two of these pairs informative data were obtained as to their clonal relationship. In both pairs similarities were found between the tumors from the right and left side strongly indicating that bilaterality had occurred via a metastatic process. The bilateral tumors as a group showed more aberrations than did the unilateral ones consistent with the view that bilaterality is a sign of more advanced disease. Conclusion Because some of the imbalances found in borderline ovarian tumors seem to be similar to imbalances already known from the more extensively studied
