Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins | Buonomo et al. Journal of Translational Medicine 2011 9 2 http content 9 1 2 TRANSLATIONAL MEDICINE RESEARCH Open Access Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6 E7 oncoproteins 1 I z- 2 3 14 Tonia Buonomo Laura Carraresi Mara Rossini Rosanna Martinelli 1 Abstract Background Lung cancers consist of four major types that and for clinical-pathological reasons are often divided into two broad categories small cell lung cancer SCLC and non-small cell lung cancer NSCLC . All major histological types of lung cancer are associated with smoking although the association is stronger for SCLC and squamous cell carcinoma than adenocarcinoma. To date epidemiological studies have identified several environmental genetic hormonal and viral factors associated with lung cancer risk. It has been estimated that 15-25 of human cancers may have a viral etiology. The human papillomavirus HPV is a proven cause of most human cervical cancers and might have a role in other malignancies including vulva skin oesophagus head and neck cancer. HPV has also been speculated to have a role in the pathogenesis of lung cancer. To validate the hypothesis of HPV involvement in small cell lung cancer pathogenesis we performed a gene expression profile of transgenic mouse model of SCLC induced by HPV-16 E6 E7 oncoproteins. Methods Gene expression profile of SCLC has been performed using Agilent whole mouse genome 4 X 44k representing 41000 genes and mouse transcripts. Samples were obtained from two HPV16-E6 E7 transgenic mouse models and from littermate s normal lung. Data analyses were performed using GeneSpring 10 and the functional classification of deregulated genes was performed using Ingenuity Pathway Analysis Ingenuity Systems http . Results Analysis of deregulated genes induced by the expression of E6 E7 oncoproteins supports the hypothesis of a linkage between HPV infection
