Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse | BioMed Central Virology Journal Research Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse Krystyna Mozdzanowska1 Darya Zharikova1 2 Mare Cudic1 3 Laszlo Otvos1 4 and Walter Gerhard 1 Open Access Address immunology Program The Wistar Institute Philadelphia USA 2Department of Pathology and Laboratory Medicine University of Wisconsin Hospital and Clinics Madison USA 3Department of Chemistry and Biochemistry Florida Atlantic University Boca Raton USA and 4Temple University Sbarro Institute Philadelphia USA Email Krystyna Mozdzanowska - kmoz@ Darya Zharikova - DZharikova@ Mare Cudic - mcudic@ Laszlo Otvos - otvos@ Walter Gerhard - gerhard@ Corresponding author Published 31 October 2007 Received 6 September 2007 Accepted 31 October 2007 Virology Journal 2007 4 118 doi l743-422X-4-ll8 This article is available from http content 4 l l 18 2007 Mozdzanowska et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The M2 ectodomain M2e of influenza A virus IAV strains that have circulated in humans during the past 90 years shows remarkably little structural diversity. Since M2e-specific antibodies Abs are capable of restricting IAV replication in vivo but are present only at minimal concentration in human sera efforts are being made to develop a M2e-specific vaccine. We are exploring a synthetic multiple antigenic peptide MAP vaccine and here report on the role of adjuvants cholera toxin and immunostimulatory oligodeoxynucleotide and route of immunization on Ab response and strength of protection. Results Independent of .
