Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis | Journal of Neuroinflammation BioMed Central Research Open Access Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis Cecile Canova 1 Jim W Neal2 and Philippe Gasque 1 3 Address 1Brain Inflammation and Immunity Group Department of Medical Biochemistry Cardiff University Heath Park Cardiff CF14 4XN UK 2Department of Pathology Neuropathology Laboratory Cardiff University Heath Park Cardiff CF14 4XN UK and 3LBGM Faculty of Sciences and Technologies University of la Reunion 15 Avenue René Cassin BP7151 97715 Saint Denis Reunion Email Cecile Canova - canova_cecile@ Jim W Neal - jwneal@ Philippe Gasque - gasque@ Corresponding author Published 02 September 2006 Received 19 April 2006 Accepted 02 September 2006 Journal of Neuroinflammation 2006 3 22 doi 1742-2094-3-22 This article is available from http content 3 1 22 2006 Canova et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In meningitis the cerebrospinal fluid contains high levels of innate immune molecules . complement which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes neutrophils monocytes . However epithelial cells of either the ependymal layer one of the established niche for adult neural stem cells or of the choroid plexus may be extremely vulnerable to bystander attack by cytotoxic and cytolytic complement components. Methods In this study we assessed the capacity of brain epithelial cells to express membranebound complement regulators ie CD35 CD46 CD55 and CD59 in vitro and in situ by immunostaining of control and meningitis human brain tissue sections. Results .
