Tham khảo tài liệu 'báo cáo hóa học: " repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (rest/nrsf) can regulate hsv-1 immediate-early transcription via histone modification"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | BioMed Central Virology Journal Research Open Access Repressor element-1 silencing transcription factor neuronal restrictive silencer factor REST NRSF can regulate HSV-1 immediate-early transcription via histone modification Rajeswara C Pinnoji1 Gautam R Bedadala1 Beena George1 Thomas C Holland2 James M Hill3 and Shao-chung V Hsia 1 Address Department of Basic Pharmaceutical Sciences College of Pharmacy The University of Louisiana at Monroe 700 University Avenue Monroe LA 71209 USA 2Department of Immunology and Microbiology School of Medicine Wayne State University 540 East Canfield Avenue Detroit MI 48201 USA and 3Department of Ophthalmology Neuroscience Pharmacology and Microbiology LSU Eye Center and LSU Health Sciences Center New Orleans LA 70118 USA Email Rajeswara C Pinnoji - prajeshwarachary@ Gautam R Bedadala - Gautam_744@ Beena George - beenaq79@ Thomas C Holland - James M Hill - jhill@ Shao-chung V Hsia - hsia@ Corresponding author Published 7 June 2007 Received 23 March 2007 Accepted 7 June 2007 Virology Journal 2007 4 56 doi l 743-422X-4-56 This article is available from http content 4 1 56 2007 Pinnoji et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background During primary infection of its human host Herpes Simplex Virus Type-1 HSV-1 establishes latency in neurons where the viral genome is maintained in a circular form associated with nucleosomes in a chromatin configration. During latency most viral genes are silenced although the molecular mechanisms responsible for this are unclear. We hypothesized that neuronal factors repress HSV-1 gene expression during latency. A search of the HSV-1 DNA .
