Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement | Sepah et al. Journal of Orthopaedic Surgery and Research 2011 6 22 http content 6 1 22 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement Yasir J Sepah1 Masood Umer2 Tashfeen Ahmad3 Faria Nasim1 Muhammad Umer Chaudhry1 and Muhammad Umar4 Abstract Background Purpose Allogenic blood transfusion in elective orthopaedic surgery is best avoided owing to its associated risks. Total knee replacement often requires blood transfusion more so when bilateral surgery is performed. Many strategies are currently being employed to reduce the amount of peri-operative allogenic transfusions. Anti-fibrinolytic compounds such as aminocaproic acid and tranexamic acid have been used systemically in perioperative settings with promising results. This study aimed to evaluate the effectiveness of tranexamic acid in reducing allogenic blood transfusion in total knee replacement surgery. Methodology This was a retrospective cohort study conducted on patients undergoing total knee replacement during the time period November 2005 to November 2008. Study population was 99 patients of which 70 underwent unilateral and 29 bilateral knee replacement. Forty-seven patients with 62 knees group-I had received tranexamic acid by surgeon preference while the remaining fifty-two patients with 66 knees group-II had did not received any tranexamic acid either pre- or post-operatively. Results The mean drop in the post-operative haemoglobin concentration in Group-II for unilateral and bilateral cases was gm dl and gm dl with a mean post-operative drainage of 1828 ml unilateral and 2695 ml bilateral . In comparison the mean drop in the post-op haemoglobin in Group-I was gm dl unilateral and gm dl bilateral with a mean drainage of 826 ml unilateral and 1288 ml bilateral p-value . Interpretation Tranexamic acid is .
