Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype | Journal of Ovarian Research BioMed Central Open Access Review Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype Nicholas B Berry and Sharmila A Bapat Address National Centre for Cell Science NCCS Complex Pune University Campus Pune 411007 INDIA Email Nicholas B Berry - Sharmila A Bapat - sabapat@ Corresponding author Published 24 November 2008 Received 10 September 2008 Journal of Ovarian Research 2008 1 8 doi 1757-2215-1-8 Accepted 24 November 2008 This article is available from http content l l 8 2008 Berry and Bapat licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Aggressive epithelial ovarian cancer EOC is genetically and epigenetically distinct from normal ovarian surface epithelial cells OSE and early neoplasia. Co-expression of epithelial and mesenchymal markers in EOC suggests an involvement of epithelial-mesenchymal transition EMT in cancer initiation and progression. This phenomenon is often associated with acquisition of a stem cell-like phenotype and chemoresistance that correlate with the specific gene expression patterns accompanying transformation revealing a plasticity of the ovarian cancer cell genome during disease progression. Differential gene expressions between normal and transformed cells reflect the varying mechanisms of regulation including genetic changes like rearrangements within the genome as well as epigenetic changes such as global genomic hypomethylation with localized promoter CpG island hypermethylation. The similarity of gene expression between ovarian cancer cells and the stem-like ovarian cancer initiating cells OCIC are surprisingly also correlated with epigenetic .
