Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A facile iodine(III)-mediated synthesis of 3-(3-aryl1-phenyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a] pyridines via oxidation of 2-((3-aryl-1-phenyl-1Hpyrazol-4-yl)methylene)-1-(pyridin-2-yl)hydrazines and their antimicrobial evaluations | Prakash et al. Organic and Medicinal Chemistry Letters 2011 1 1 http content 1 1 1 o Organic and Medicinal Chemistry Letters a SpringerOpen Journal ORIGINAL Open Access A facile iodine III -mediated synthesis of 3- 3-aryl-1-phenyl-1 H-pyrazol-4-yl - 1 2 4 triazolo 4 3-a pyridines via oxidation of 2- 3-aryl-1-phenyl-1H-pyrazol-4-yl methylene -1- pyridin-2-yl hydrazines and their antimicrobial evaluations 1 2 2 3 3 Om Prakash Khalid Hussain Deepak K Aneja Chetan Sharma and Kamal R Aneja Abstract Background Fused heterocyclic 1 2 4-triazoles have acquired much importance because of their interesting biological properties. Although a number of methods have been reported in the literature which includes oxidation with phosphorus oxychloride lead tetraacetate bromine etc. hypervalent iodine reagents have emerged as reagents of choice for various synthetically useful transformations due to their low toxicity ready availability and ease of handling. Results A series of new 3- 3-aryl-1-phenyl-7H-pyrazol-4-yl - 1 2 4 triazolo 4 3-a pyridines 4 has been conveniently synthesized by oxidative cyclization of 2- 3-aryl-1-phenyl-1H-pyrazol-4-yl methylene -1- pyridin-2-yl hydrazines 3 promoted with iodobenzene diacetate under mild conditions up to 90 isolated yields . All the new compounds were tested in vitro for their antimicrobial activity. Conclusions Iodine III -mediated oxidative approach has offered an easy access to new 3- 3-aryl-1-phenyl-1H-pyrazol-4-yl - 1 2 4 triazolo 4 3-a pyridines 4. The antibacterial and antifungal activities of newly synthesized compounds have proved them potent antimicrobial agents. Keywords hypervalent iodine antimicrobial activity triazoles pyrazole Background Fused heterocyclic 1 2 4-triazoles have acquired much importance because of their CNS depressant 1 antiallergy 2 antimicrobial 3 and anti-inflammatory 4 properties. Most methods for the preparation of fused 1 2 4-triazole derivatives are based on the oxidation of .
