Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Exploring the Immunotoxicity of Carbon Nanotubes | Nanoscale Res Lett 2008 3 271-277 DOI S11671-008-9153-1 NANO REVIEW Exploring the Immunotoxicity of Carbon Nanotubes Yanmei Yu Qiu Zhang Qingxin Mu Bin Zhang Bing Yan Received 14 June 2008 Accepted 16 July 2008 Published online 20 August 2008 to the authors 2008 Abstract Mass production of carbon nanotubes CNTs and their applications in nanomedicine lead to the increased exposure risk of nanomaterials to human beings. Although reports on toxicity of nanomaterials are rapidly growing there is still a lack of knowledge on the potential toxicity of such materials to immune systems. This article reviews some existing studies assessing carbon nanotubes toxicity to immune system and provides the potential mechanistic explanation. Keywords Nanotube Nanoparticle Nanomaterial Immunity Cytokine Macrophage Animal study Cell culture Nano-combinatorial chemistry Nanotoxicity Introduction Carbon nanotubes CNTs are cylindrical molecules with a length of up to micrometers and a diameter of nm for single-walled carbon nanotubes SWNTs and 2-100 nm for coaxial multi-walled carbon nanotubes MWNTs . CNTs have long been speculated and tested as new materials for biological and biomedical applications. Because of their abilities to bind cells and across the cell membrane 1 2 Yanmei Yu and Qiu Zhang contributed equally to this work. Y. Yu Q. Zhang Q. Mu B. Zhang B. Yan School of Pharmaceutical Sciences Shandong University Jinan China Q. Mu B. Yan H Department of Chemical Biology and Therapeutics St. Jude Children s Research Hospital 332 North Lauderdale Street Memphis TN 38105 USA e-mail functionalized CNTs can be used as nanovectors for drug delivery and cancer phototherapy 3 . On the other hand when injected intravenously CNTs will interact directly with immune cells and proteins in blood and tissues. Immunotoxicity is one of the consequences of using nanoparticles. Immunity is the function of the body to recognize and eliminate pathogens and foreign .
