Moreover, during the past years, intensive and repeated applications of the same active ingredients cause the selection for and development of herbicide resistance (Devine & Shukla, 2000; Beckie, 2006; Gressel, 2009; Preston, 2004). Starting from 1960s, hundreds of weed biotypes have been reported as surviving herbicide application (Heap, 2011). Intensive efforts have thus been undertaken to discover new compounds with favorable environmental and safety features to selectively control weeds. In this regard, the photosynthetic system has been target aiming to find new weed killers. In this book chapter, it will be covered the developments concerning the search for new photosynthetic inhibitors during the last ten years