They give sodium tail currents with relative longterm constants (Wright, et al., 1988). At lower doses more suble repetitive behavior is seen (Brodie and Aldridge, 1982). As with type I pyrethroids, the primary action is on the central nervous system, since symptoms correlate well with brain concentrations (Rickard and Brodie, 1985). As might be expected, both classes of parathyroid produce large increases in brain glucose utilization (Cremer et al. 1983). A final factor distinguishing type 11 pyrethroids is their ability to depress resting chloride conductance, thereby amplifying any sodium or calcium effects (Forshaw and Ray, 1990). Intermediate signs representing a combination of type I and type 11 are.
